2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-131562
    2'-F-dUTP 66840-02-6 98%
    2'-F-dUTP (2'-Fluoro-dUTP) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-F-dUTP
  • HY-131563
    2'-F-dCTP 66840-03-7 98%
    2'-F-dCTP is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-F-dCTP
  • HY-131663
    L-Lysinamide 32388-19-5 98%
    L-Lysinamide is an amide form of L-Lysine (HY-N0469). L-Lysinamide can be conjugated with Cholesterol (HY-N0322) and L-ornithinamide for use as a DNA delivery agent.
    L-Lysinamide
  • HY-131701
    Lactosyl-C18-sphingosine 109785-20-8 98%
    Lactosyl-C18-sphingosine (C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine) is a bioactive sphingolipid that is a form of lactosylceramide but lacks the fatty acyl group. Lysolactosylceramide (1-50 μM) reduces the viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide, Lactosyl-C18-sphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosyl-C18-sphingosine is a lysoganglioside GM3.
    Lactosyl-C18-sphingosine
  • HY-131728
    GPR35 agonist 3 123021-85-2 98.32%
    GPR35 agonist 3 is a synthetic GPR35 agonist with an EC50value of 1.4 μM. GPR35 agonist 3 can be used for the research of various diseases, such as gastric cancer, type 2 diabetes, cardiovascular diseases, immune system and peripheral nervous system.
    GPR35 agonist 3
  • HY-131787
    2-Amino-ATP 18549-34-3 98%
    2-Amino-ATP is a monomeric raw material that can be used for nucleic acid synthesis.
    2-Amino-ATP
  • HY-133003
    L662,025 122328-38-5 98%
    L662,025 is a specific, photolabile and irreversible Platelet-activating factor (PAF-receptor) antagonist, with IC50 values of 5.6 μM (platelet aggregation) and 1 μM (receptor binding), respectively.
    L662,025
  • HY-133179
    Wnt/β-catenin-IN-4 2131223-69-1 98%
    Wnt/β-catenin-IN-4 (compound YW1159) is a potent Wnt/β-catenin inhibitor.
    Wnt/β-catenin-IN-4
  • HY-133775
    Olmesartan impurity 154709-18-9 98%
    Olmesartan impurity is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist has the potential for high blood pressure study.
    Olmesartan impurity
  • HY-133969
    5β-Cholane 80373-86-0 98%
    5β-Cholane is a farnesoid X receptor (FXR) activator. 5β-Cholane can be used for the research of cholesterol and lipid-related diseases.
    5β-Cholane
  • HY-133975
    Isoleucylcysteine 117525-90-3 98%
    Isoleucylcysteine, a dipeptide composed of isoleucine and cysteine, is an intermediate peptide in bacitracin biosynthesis.
    Isoleucylcysteine
  • HY-134055
    Arachidonoyl-N,N-dimethyl amide 45280-17-9 99.9%
    Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N,N-dimethyl amide is an analog of anandamide that exhibits weak or no binding to the human central cannabinoid (CB1) receptor (Ki >1 μM). It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
    Arachidonoyl-N,N-dimethyl amide
  • HY-134075
    2-Amino-2'-O-methyladenosine 80791-87-3 98%
    2-Amino-2'-O-methyladenosine (2'-O-Me-2-NH?-rA) is a monomeric raw material that can be used for nucleic acid synthesis.
    2-Amino-2'-O-methyladenosine
  • HY-134076
    2',3'-Di-O-Methyladenosine 20649-46-1 98%
    2',3'-Di-O-Methyladenosine (2',3'-O-Me-rA) is a monomeric raw material that can be used for nucleic acid synthesis.
    2',3'-Di-O-Methyladenosine
  • HY-13409R
    SB 242084 (Standard) 181632-25-7 98%
    SB 242084 (Standard) is the analytical standard of SB 242084. This product is intended for research and analytical applications. SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.
    SB 242084 (Standard)
  • HY-134110
    N-Methylarachidonamide 156910-29-1 99.9%
    Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
    N-Methylarachidonamide
  • HY-134157
    cis-10-Nonadecenoic acid methyl ester 19788-74-0 98%
    cis-10-Nonadecenoic acid methyl ester is an unsaturated fatty acid methyl ester (FAME)。
    cis-10-Nonadecenoic acid methyl ester
  • HY-134177
    2,5-Anhydro-D-glucitol-1,6-diphosphate 4429-47-4 99.49%
    2,5-Anhydro-D-glucitol-1,6-diphosphate is a limited stimulator of yeast Pyruvate Kinase. 2,5-Anhydro-D-glucitol-1,6-diphosphate is used as an analogue of the a-form, 2,5-anhydro-D-mannitol 1,6-bisphosphate, while is an excellent allosteric activator of Pyruvate Kinase.
    2,5-Anhydro-D-glucitol-1,6-diphosphate
  • HY-134223
    1,3-Diarachidoyl glycerol 59925-28-9 98%
    1,3-Diarachidoyl glycerol is a diacylglycerol that contains Arachidic acid (HY-W004260).
    1,3-Diarachidoyl glycerol
  • HY-134225
    1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-PC 86288-11-1 98%
    1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-PC (16:0e/20:4-GPC) is an alkylether-glycerophosphocholine (GPC).
    1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-PC
Cat. No. Product Name / Synonyms Application Reactivity